Benefits of Collagen Tablets
Key Findings
Oral collagen supplementation, particularly from fish collagen, has been consistently associated with favorable outcomes for skin, bone, and muscular health, including improved skin hydration, elasticity, and reduced wrinkles [1] [2] [3].
Punica granatum (pomegranate) extracts demonstrate a broad range of dermocosmetic properties, such as antioxidant, anti-inflammatory, wound healing, and collagen-preserving effects, primarily due to compounds like ellagitannins and flavonoids [4].
Astaxanthin, a potent antioxidant, has shown benefits in reducing oxidative stress, inhibiting collagen degradation, and improving skin integrity when combined with collagen peptides and vitamins [5] [6] [7].
Introduction
This report discusses the potential health benefits of a supplement containing fish collagen, Punica granatum L., lycopene, vitamin C, piperine, and astaxanthin. These ingredients are individually recognized for various biological activities, particularly in skin health, antioxidant protection, and anti-inflammatory responses.
Main Text
Systematic Reviews and Meta-Analyses on Collagen and Skin Health
An umbrella review of systematic reviews, including 16 systematic reviews and 113 randomized controlled trials (RCTs) with 7983 patients, found that collagen supplementation consistently leads to favorable outcomes for dermal, bone, and muscular health [2]. Specifically for skin aging, a systematic review and meta-analysis highlighted that oral fish collagen supplementation improves skin hydration, elasticity, and reduces wrinkles [1]. Another systematic review focusing on type I collagen and skin aging, which included eleven clinical studies, concluded that collagen supplementation, especially from hydrolyzed fish cartilage and low-molecular-weight peptides, enhances collagen production, improves skin hydration and texture, and reduces signs of photoaging [3].
Benefits of Punica granatum and Antioxidants
Punica granatum (pomegranate) extracts exhibit diverse dermocosmetic properties, including antioxidant, anti-inflammatory, antibacterial, wound healing, moisturizing, photoprotective, and collagen-preserving effects [4]. These effects are attributed to compounds like ellagitannins, ellagic and gallic acid, and flavonoids. Pomegranate also modulates oxidative stress by scavenging reactive oxygen species and upregulating Nrf2-mediated antioxidant pathways, and inhibits matrix metalloproteinases (MMP-1 and MMP-3) [4]. Preclinical studies indicate that punicalagin, a major component of pomegranate, reduces oxidative stress via Nrf2/HO-1 and AMPK pathways and suppresses inflammatory cytokines [8].
Astaxanthin, a powerful carotenoid, is noted for its exceptional antioxidant potency, surpassing α-tocopherol (Vitamin E) by 100-fold [6] [7]. A study on UV-induced BALB/c mice demonstrated that a combination of collagen peptide (CP), Haematococcus pluvialis extract (HPE, a source of astaxanthin), vitamin C (Vc), and vitamin E (Ve) significantly (P < 0.05) reduced skin redness, increased hydroxyproline and type I collagen content, and improved skin integrity. This combination also showed increased upregulation of antioxidant enzyme expression and reduced serum reactive oxygen species (ROS) [5].
While the provided results discuss the benefits of fish collagen, Punica granatum L., lycopene, vitamin C, and astaxanthin individually or in some combinations, there is no specific study among the top results that directly investigates the combined effect of all six ingredients (fish collagen, Punica granatum L., lycopene, vitamin C, piperine, and astaxanthin) in the precise proportions mentioned in the user's query. The role of piperine in this specific combination is not detailed in the provided literature.
Conclusions
Oral supplementation with fish collagen, Punica granatum L., lycopene, vitamin C, and astaxanthin offers a range of health benefits, particularly for skin health and antioxidant protection. Fish collagen consistently demonstrates benefits for skin hydration, elasticity, and wrinkle reduction. Punica granatum L. provides antioxidant, anti-inflammatory, and collagen-preserving effects. Astaxanthin, combined with collagen and vitamins, further enhances antioxidant defense and improves skin integrity. The specific combined effect of all six ingredients, including piperine, at the given dosages, has not been directly evaluated in the provided literature.
References:
1) The Effectiveness of Oral Fish Collagen Supplementation on Skin Aging: A Systematic Review and Meta-analysis of Skin Hydration, Skin Elasticity, and Skin Wrinkles. American Journal of Dermatological Research and Reviews (2023). https://escipub.com/ajodrr-2023-01-0505ig/
2) R Ravindran et al. Collagen Supplementation for Skin and Musculoskeletal Health: An Umbrella Review of Meta-Analyses on Elasticity, Hydration, and Structural Outcomes. Aesthetic surgery journal. Open forum (2026). https://pubmed.ncbi.nlm.nih.gov/41809116/
3) Ofek Bar et al. Skin Aging and Type I Collagen: A Systematic Review of Interventions with Potential Collagen-Related Effects. Cosmetics (2025). https://www.mdpi.com/2079-9284/12/4/129
4) N Pons-Rocamora et al. Dermocosmetic Potential of Punica granatum: A Systematic Review of Bioactive Compounds and Skincare Applications. Antioxidants (Basel, Switzerland) (2026). https://pubmed.ncbi.nlm.nih.gov/41897478/
5) B Song et al. The combined effect of commercial tilapia collagen peptides and antioxidants against UV-induced skin photoaging in mice. Food & function (2023). https://pubmed.ncbi.nlm.nih.gov/37337869/
6) Natalia Małek et al. Benefits of Astaxanthin supplementation: selected issues. Quality in Sport (2024). https://apcz.umk.pl/QS/article/view/55861
7) A Donoso et al. "Therapeutic uses of natural astaxanthin: An evidence-based review focused on human clinical trials". Pharmacological research (2021). https://pubmed.ncbi.nlm.nih.gov/33549728/
8) G Kaur et al. Cardioprotective potential of punicalagin: an evidence-based review. Journal of Asian natural products research (2026). https://pubmed.ncbi.nlm.nih.gov/41755506/