Benefits of Cardio¹ Balance Card

Benefits of Cardio¹ Balance Card

Key Findings

  • Omega-3 fatty acids and folic acid have demonstrated benefits in reducing the risk of cardiovascular disease (CVD) mortality, myocardial infarction, coronary heart disease events, and stroke [1].
  • Curcumin supplementation has been shown to significantly improve flow-mediated dilation (FMD), an important marker of endothelial function, while reducing inflammatory biomarkers including C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) [2][3].
  • Magnesium and vitamin D3 demonstrated the greatest improvements in endothelial function, measured by FMD, among individuals with cardiovascular disease and hypertension [4].

Introduction

Cardiovascular disease remains one of the leading causes of morbidity and mortality worldwide. Nutrition plays an important role in supporting cardiovascular health by contributing to normal physiological processes involved in vascular function, inflammation, and lipid metabolism. In addition, several vitamins, minerals, and plant-derived compounds have been investigated for their ability to support normal immune function and help regulate inflammatory processes that are closely linked to cardiovascular health [1][7].

This report reviews the scientific evidence supporting a comprehensive nutrient formulation containing magnesium, omega-3 fatty acids, curcumin, B vitamins, vitamin C, vitamin D3, vitamin E, selenium, zinc, fenugreek, taurine, Andrographis paniculata, citrus bioflavonoids, echinacea, ginkgo biloba, Siberian ginseng, and Lactospore®. Together, these ingredients provide nutritional support for cardiovascular function, endothelial health, immune function, and the body's normal inflammatory response.

Main Text

Cardiovascular Health Support

A substantial body of clinical evidence demonstrates that several vitamins, minerals, and bioactive compounds can contribute to cardiovascular health by supporting endothelial function, reducing inflammation, and improving established cardiovascular risk factors.

A comprehensive meta-analysis of 884 randomized controlled intervention trials involving 883,627 participants evaluated the effects of multiple micronutrient interventions on cardiovascular disease risk. The analysis found moderate- to high-quality evidence supporting the benefits of several nutrients, including omega-3 fatty acids, folic acid, vitamin D, and magnesium, in reducing cardiovascular risk factors [1].

Omega-3 Fatty Acids

Omega-3 fatty acid supplementation was associated with significant reductions in several major cardiovascular outcomes, including:

  • Cardiovascular disease mortality (RR: 0.93; 95% CI: 0.88–0.97)
  • Myocardial infarction (RR: 0.85; 95% CI: 0.78–0.92)
  • Coronary heart disease events (RR: 0.86; 95% CI: 0.80–0.93) [1].

These findings were further supported by a randomized, double-blind, placebo-controlled clinical trial involving 53 adults with elevated blood pressure. After 90 days of supplementation, participants demonstrated significant increases in circulating EPA, DPA, and total omega-3 fatty acid levels, accompanied by a favourable trend towards improved endothelial function [5].

Folic Acid

Folic acid supplementation was associated with a significant reduction in stroke risk (RR: 0.84; 95% CI: 0.72–0.97), highlighting its potential role in supporting cardiovascular health [1].

Curcumin

Curcumin has been extensively investigated for its effects on vascular health.

A meta-analysis of ten randomized controlled trials demonstrated that curcumin supplementation significantly improved flow-mediated dilation (FMD), a recognised indicator of endothelial function (WMD: 1.49; 95% CI: 0.16–2.82) [3].

A more recent meta-analysis of meta-analyses confirmed these findings, reporting a significant improvement in FMD (WMD: 1.64; 95% CI: 1.06–2.22). The same analysis also demonstrated a reduction in pulse wave velocity (PWV) (WMD: -45.60; 95% CI: -88.16 to -3.04), suggesting improved arterial function [2].

Magnesium and Vitamin D3

A network meta-analysis comparing multiple dietary interventions for endothelial function among individuals with cardiovascular disease and hypertension identified magnesium (MD: 8.17) and vitamin D3 (MD: 7.84) as the interventions associated with the greatest improvements in flow-mediated dilation [4].

Additional evidence suggests that vitamins D, E, and C, together with magnesium and zinc, may contribute to reduced platelet aggregation, lower oxidative stress, decreased systemic inflammation, and improved endothelial function, particularly in individuals with insulin resistance [6].

Immune Function and Inflammatory Response

Chronic low-grade inflammation is recognised as an important contributor to cardiovascular disease. Several nutrients included in the Cardio¹ Balance Card have demonstrated the ability to support normal immune function while helping regulate inflammatory processes.

A review of 87 clinical trials concluded that numerous nutrients and phytonutrients—including curcumin, omega-3 fatty acids, selenium, zinc, and vitamins B12, C, D3, and E—can significantly influence immune function and inflammatory pathways [7].

These interventions affected several important biomarkers involved in immune regulation, including:

  • Nuclear factor-kappa B (NF-κB)
  • Tumour necrosis factor-alpha (TNF-α)
  • Interleukin-6 (IL-6)
  • CD4+ T lymphocytes [7].

Curcumin and Inflammation

Curcumin supplementation demonstrated significant reductions in multiple inflammatory biomarkers, including:

  • C-reactive protein (CRP) (WMD: -0.87)
  • Tumour necrosis factor-alpha (TNF-α) (WMD: -2.72)
  • Interleukin-6 (IL-6) (WMD: -0.97) [2].

These findings suggest that curcumin may support the body's normal inflammatory response.

Micronutrients Supporting Immune Function

Optimal nutritional status is essential for maintaining a well-functioning immune system.

Scientific evidence indicates that adequate intake of vitamins A, B6, B12, C, D, and E, together with folate, zinc, iron, selenium, magnesium, copper, and omega-3 fatty acids, supports normal immune cell function and contributes to protection against viral infections [8][9][10].

Supplementation with these nutrients has been described as a safe, effective, and relatively low-cost strategy for supporting immune health when dietary intake is insufficient [8][10].

Additional evidence highlights the importance of magnesium, zinc, selenium, vitamins C, D, E, and B vitamins in supporting cytokine production, immune cell differentiation, antioxidant defence, and the neutralisation of free radicals. Omega-3 fatty acids have also demonstrated strong anti-inflammatory properties while supporting normal immune cell function [11].

Conclusion

The available scientific literature supports the potential benefits of several ingredients included in the Cardio¹ Balance Card for cardiovascular and immune health.

Omega-3 fatty acids and folic acid have demonstrated beneficial effects on major cardiovascular outcomes, including reductions in cardiovascular mortality, myocardial infarction, coronary heart disease events, and stroke risk.

Curcumin has consistently been shown to improve endothelial function while reducing several biomarkers associated with inflammation, including CRP, TNF-α, and IL-6. Magnesium and vitamin D3 have also demonstrated substantial improvements in endothelial function in individuals with cardiovascular disease and hypertension.

In addition, a broad range of micronutrients—including B vitamins, vitamins C, D3 and E, selenium, zinc, magnesium, and omega-3 fatty acids—play important roles in supporting normal immune function and helping regulate inflammatory processes.

Although the available literature does not specifically evaluate the complete combination of ingredients included in the Cardio¹ Balance Card, nor extensively investigate ingredients such as fenugreek, taurine, Andrographis paniculata, citrus bioflavonoids, echinacea, ginkgo biloba, Siberian ginseng, and Lactospore® within this formulation, the individual ingredients supported by clinical evidence demonstrate meaningful contributions to cardiovascular health, endothelial function, immune function, and the body's normal inflammatory response.

References

  1. P An et al. Micronutrient Supplementation to Reduce Cardiovascular Risk. Journal of the American College of Cardiology (2022). https://pubmed.ncbi.nlm.nih.gov/36480969/
  2. Z Kavyani et al. The effects of curcumin supplementation on biomarkers of inflammation, oxidative stress, and endothelial function: A meta-analysis of meta-analyses. Prostaglandins & Other Lipid Mediators (2024). https://pubmed.ncbi.nlm.nih.gov/38945354/
  3. J Hallajzadeh et al. The effects of curcumin supplementation on endothelial function: A systematic review and meta-analysis of randomized controlled trials. Phytotherapy Research (2019). https://pubmed.ncbi.nlm.nih.gov/31423626/
  4. M Norouzzadeh et al. Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis. Current Atherosclerosis Reports (2026). https://pubmed.ncbi.nlm.nih.gov/42277453/
  5. Ahmed Ghanem et al. Effects of Supplements Containing Curcumin, Omega Fatty Acids, Gamma-Linolenic Acid, Vitamin E, Vitamin D, Hydroxytyrosol, and Astaxanthin on Cardiovascular Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. American Journal of Preventive Cardiology (2023). https://www.sciencedirect.com/science/article/pii/S266666772200085X?via%3Dihub
  6. K Mohammadian et al. Insulin Resistance and Platelet Hyperactivity: Hematological Insights and Nutritional Strategies for Vascular Protection. Nutrients (2026). https://pubmed.ncbi.nlm.nih.gov/41829931/
  7. J Poles et al. The Effects of Twenty-Four Nutrients and Phytonutrients on Immune System Function and Inflammation: A Narrative Review. Journal of Clinical and Translational Research (2021). https://pubmed.ncbi.nlm.nih.gov/34239993/
  8. PC Calder et al. Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect Against Viral Infections. Nutrients (2020). https://pubmed.ncbi.nlm.nih.gov/32340216/
  9. Lusamaki Mukunda François et al. Coronavirus and Nutrition: An Approach for Boosting Immune System – A Review. European Journal of Nutrition & Food Safety (2020). https://journalejnfs.com/index.php/EJNFS/article/view/503
  10. Fatemeh Shirani et al. Review on Selected Potential Nutritional Interventions for the Treatment and Prevention of Viral Infections: Possibility of Recommending These for Coronavirus Disease 2019. International Journal of Food Properties (2020). https://www.tandfonline.com/doi/full/10.1080/10942912.2020.1825483
  11. K Napiórkowska-Baran et al. Immunomodulatory Effects of Selected Non-Nutritive Bioactive Compounds and Their Role in Optimal Nutrition. Current Issues in Molecular Biology (2025). https://pubmed.ncbi.nlm.nih.gov/39996810/

Written By : VITBLISS

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