Benefits of Menopause¹ Formula Capsules

Benefits of Menopause¹ Formula Capsules

Introduction

This report discusses the potential benefits of a menopause support supplement, Menopause¹ Formula Capsules, which contains a combination of Vitamin D3, Vitamin B6, silicon from bamboo extract, soy isoflavones, black cohosh (Cimicifuga), Vitex agnus-castus, and alfalfa.

Many women seek non-hormonal alternatives to manage menopausal symptoms due to safety concerns or contraindications for hormone replacement therapy (HRT) [1][2]. The following sections present scientific findings on the individual and combined ingredients regarding their effectiveness in relieving menopausal symptoms.

Key Findings

  • A combination of black cohosh, soy isoflavones, and SDG lignans significantly reduced menopausal symptoms, with a 48.0% reduction in the total Menopause Rating Scale (MRS) score in a randomized, double-blind clinical trial [3].
  • Soy isoflavones significantly improved vaginal dryness (SMD = -1.88) and urogenital symptoms (SMD = -0.33) in a meta-analysis of randomized controlled trials [4].

  • Black cohosh extracts were associated with significant improvements in:

    • Overall menopausal symptoms (Hedges' g = 0.575)
    • Hot flashes (Hedges' g = 0.315)
    • Somatic symptoms (Hedges' g = 0.418)

    compared with placebo [5].

Systematic Reviews and Meta-Analyses

A meta-analysis of 13 randomized controlled trials (n = 1,325) showed that soy isoflavones (40–160 mg/day) significantly improved vaginal dryness and urogenital symptoms in postmenopausal women, with the greatest benefits observed at doses of 50–100 mg/day [4].

Another systematic review and meta-analysis confirmed that soy isoflavones are associated with a reduction in both the frequency and severity of hot flashes [6].

A meta-analysis of 22 studies (n = 2,310) evaluating black cohosh extracts demonstrated significant improvements in overall menopausal symptoms, hot flashes, and somatic symptoms. However, no significant improvements were observed for anxiety or depressive symptoms [5].

The Spanish Menopause Society states that black cohosh (Cimicifuga racemosa) at a dose of 40 mg/day is both effective and safe for relieving vasomotor symptoms, particularly in women experiencing severe hot flashes, and may also improve mood [7].

Randomized Controlled Trials and Observational Studies

A randomized, double-blind, placebo-controlled clinical trial involving 96 postmenopausal women (45–60 years) found that a combination of black cohosh, soy isoflavones, and SDG lignans significantly improved somatic, psychological, and urogenital Menopause Rating Scale (MRS) scores, resulting in a 48.0% reduction in the total score [3].

A controlled study involving 588 menopausal women (mean age 53.0 years) showed that a supplement containing soy isoflavones, Magnolia extract, and Agnus castus extract significantly improved the Kupperman Index (KI) score, hot flashes, night sweats, and psycho-emotional symptoms compared with a supplement containing soy isoflavones alone [8].

Another nutraceutical containing Cimicifuga racemosa, Vitex agnus-castus, hyaluronic acid, zinc, and ginger significantly reduced Kupperman Index scores in women with mild to moderate/severe menopausal symptoms, particularly improving hot flashes, insomnia, and anxiety [9].

A prospective, multicenter observational study involving 135 patients found that a dietary supplement providing 40 mg of soy isoflavones per day combined with inulin had a potentially beneficial effect on hot flashes in peri- and postmenopausal women [10].

Conclusion

The available scientific literature supports the potential benefits of several ingredients included in Menopause¹ Formula Capsules for relieving menopausal symptoms.

Soy isoflavones have been shown to improve urogenital symptoms and vaginal dryness, while also reducing the frequency and severity of hot flashes.

Black cohosh extracts contribute significantly to improvements in overall menopausal symptoms, hot flashes, and somatic complaints.

Clinical studies indicate that combinations of these ingredients, sometimes supplemented with Vitex agnus-castus and other botanical extracts, can significantly reduce vasomotor and psycho-emotional symptoms while demonstrating a favorable safety profile.

However, based on the available evidence provided, no specific scientific data were identified regarding the benefits of silicon from bamboo extract or alfalfa for menopausal symptoms.

References

  1. S Palacios et al. Improvement in menopausal symptoms with a nutritional product containing evening primrose oil, hop extract, saffron, tryptophan, vitamins B6, D3, K2, B12, and B9. European Review for Medical and Pharmacological Sciences (2023). https://pubmed.ncbi.nlm.nih.gov/37750646/
  2. R Choudhury et al. Effectiveness of Multisymptom Support for Better Relief and Alleviation of Common Effects in Perimenopause (EMBRACE PERIMENOPAUSE). Cureus (2025). https://pubmed.ncbi.nlm.nih.gov/40677428/
  3. E Pokushalov et al. Assessing the combined effects of Black Cohosh, Soy Isoflavones, and SDG Lignans on menopausal symptoms: a randomized, double-blind, placebo-controlled clinical trial. European Journal of Nutrition (2025). https://pubmed.ncbi.nlm.nih.gov/40131516/
  4. A Yildiz Karaahmet et al. Soy isoflavone supplementation and sexual function in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials. International Journal of Impotence Research (2026). https://pubmed.ncbi.nlm.nih.gov/42032055/
  5. R Sadahiro et al. Black cohosh extracts in women with menopausal symptoms: an updated pairwise meta-analysis. Menopause (2023). https://pubmed.ncbi.nlm.nih.gov/37192826/
  6. Thaís Marina Hamdan Siquara Garcia et al. Major scientific evidence of the increase in women's quality of life with the use of phytoestrogens: a systematic review. International Journal of Nutrology (2025). https://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/469
  7. C Castelo-Branco et al. Black cohosh efficacy and safety for menopausal symptoms. The Spanish Menopause Society statement. Gynecological Endocrinology (2022). https://pubmed.ncbi.nlm.nih.gov/35403534/
  8. Vincenzo De Leo et al. Clinical Activity of a Combination of Isoflavones, Agnus castus and Magnolia in the Menopause: A Controlled Study on Estromineral Serena Plus. Gynecology & Obstetrics (2020). https://www.longdom.org/open-access/clinical-activity-of-a-combination-of-isoflavones-agnus-castus-and-magnolia-in-the-menopause-a-controlled-study-on-estro.pdf/
  9. V Cappelli et al. Evaluation of the efficacy of a new nutraceutical product in the treatment of postmenopausal symptoms. Minerva Ginecologica (2016). https://pubmed.ncbi.nlm.nih.gov/26788874/
  10. A Cianci et al. Soy isoflavones, inulin, calcium, and vitamin D3 in post-menopausal hot flushes: an observational study. Clinical and Experimental Obstetrics & Gynecology (2016). https://pubmed.ncbi.nlm.nih.gov/26753476/

Scritto da: VITBLISS

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